Michel Mittelbronn

Latest publications

Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors.

  • Luxembourg Center of Neuropathology
May 01, 2020
2020 May. J Clin Invest.130(5):2488-2495.
By:
  • Ronellenfitsch MW
  • Harter PN
  • Kirchner M
  • Heining C
  • Hutter B
  • Gieldon L
  • Schittenhelm J
  • Schuhmann MU
  • Tatagiba M
  • Marquardt G
  • Wagner M
  • Endris V
  • Brandts CH
  • Mautner VF
  • Schrock E
  • Weichert W
  • Brors B
  • von Deimling A
  • Mittelbronn M
  • Steinbach JP
  • Reuss DE
  • Glimm H
  • Stenzinger A
  • Frohling S.

High density DNA methylation array is a reliable alternative for PCR-based analysis of the MGMT promoter methylation status in glioblastoma.

  • Luxembourg Center of Neuropathology
January 01, 2020
2020 Jan. Pathol Res Pract.216(1):152728. Epub 2019 Nov 11.
By:
  • Braczynski AK
  • Capper D
  • Jones DTW
  • Schittenhelm J
  • Stichel D
  • von Deimling A
  • Harter PN
  • Mittelbronn M.

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

  • Luxembourg Center of Neuropathology
January 01, 2020
2020 Jan. Acta Neuropathol.139(1):193-209. Epub 2019 Sep 28.
By:
  • Wefers AK
  • Stichel D
  • Schrimpf D
  • Coras R
  • Pages M
  • Tauziede-Espariat A
  • Varlet P
  • Schwarz D
  • Soylemezoglu F
  • Pohl U
  • Pimentel J
  • Meyer J
  • Hewer E
  • Japp A
  • Joshi A
  • Reuss DE
  • Reinhardt A
  • Sievers P
  • Casalini MB
  • Ebrahimi A
  • Huang K
  • Koelsche C
  • Low HL
  • Rebelo O
  • Marnoto D
  • Becker AJ
  • Staszewski O
  • Mittelbronn M
  • Hasselblatt M
  • Schittenhelm J
  • Cheesman E
  • de Oliveira RS
  • Queiroz RGP
  • Valera ET
  • Hans VH
  • Korshunov A
  • Olar A
  • Ligon KL
  • Pfister SM
  • Jaunmuktane Z
  • Brandner S
  • Tatevossian RG
  • Ellison DW
  • Jacques TS
  • Honavar M
  • Aronica E
  • Thom M
  • Sahm F
  • von Deimling A
  • Jones DTW
  • Blumcke I
  • Capper D.

Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation.

  • Luxembourg Center of Neuropathology
January 01, 2020
2020 Jan. J Neurooncol.146(1):63-69. Epub 2019 Nov 11.
By:
  • Baumann C
  • Tichy J
  • Schaefer JH
  • Steinbach JP
  • Mittelbronn M
  • Wagner M
  • Foerch C.

Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.

  • Luxembourg Center of Neuropathology
December 01, 2019
2019 Dec. Neurobiol Dis.132:104559. Epub 2019 Jul 31.
By:
  • Sen NE
  • Canet-Pons J
  • Halbach MV
  • Arsovic A
  • Pilatus U
  • Chae WH
  • Kaya ZE
  • Seidel K
  • Rollmann E
  • Mittelbronn M
  • Meierhofer D
  • De Zeeuw CI
  • Bosman LWJ
  • Gispert S
  • Auburger G.

Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases.

  • Luxembourg Center of Neuropathology
October 29, 2019
2019 Oct. J Exp Clin Cancer Res.38(1):434.
By:
  • Bernatz S
  • Ilina EI
  • Devraj K
  • Harter PN
  • Mueller K
  • Kleber S
  • Braun Y
  • Penski C
  • Renner C
  • Halder R
  • Jennewein L
  • Solbach C
  • Thorsen F
  • Pestalozzi BC
  • Mischo A
  • Mittelbronn M.

Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas.

  • Luxembourg Center of Neuropathology
August 01, 2019
2019 Aug. Acta Neuropathol.138(2):331-334. Epub 2019 May 7.
By:
  • Filipski K
  • Braun Y
  • Zinke J
  • Roller B
  • Baumgarten P
  • Wagner M
  • Senft C
  • Zeiner PS
  • Ronellenfitsch MW
  • Steinbach JP
  • Plate KH
  • Gasparoni G
  • Mittelbronn M
  • Capper D
  • Harter PN.

Mistletoe-based drugs work in synergy with radio-chemotherapy in the treatment of glioma in vitro and in vivo in glioblastoma bearing mice.

  • Luxembourg Center of Neuropathology
July 03, 2019
2019 Jul. Evid Based Complement Alternat Med.2019:2019/07/30.
By:
  • Schotterl S
  • Miemietz JT
  • Ilina EI
  • Wirsik NM
  • Ehrlich I
  • Gall A
  • Huber SM
  • Lentzen H
  • Mittelbronn M
  • Naumann U.

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • NORLUX Neuro-Oncology Laboratory
  • Computational Biomedicine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
By:
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.

Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma.

  • Luxembourg Center of Neuropathology
May 01, 2019
2019 May. Cancer Res.29(9):2298-2313. Epub 2019 Feb 4.
By:
  • Mastrella G
  • Hou M
  • Li M
  • Stoecklein VM
  • Zdouc N
  • Volmar MNM
  • Miletic H
  • Reinhard S
  • Herold-Mende CC
  • Kleber S
  • Eisenhut K
  • Gargiulo G
  • Synowitz M
  • Vescovi AL
  • Harter PN
  • Penninger JM
  • Wagner E
  • Mittelbronn M
  • Bjerkvig R
  • Hambardzumyan D
  • Schuller U
  • Tonn JC
  • Radke J
  • Glass R
  • Kalin RE.

Therapeutic targeting of Stat3 using lipopolyplex nanoparticle-formulated siRNA in a syngeneic orthotopic mouse glioma model.

  • Luxembourg Center of Neuropathology
March 08, 2019
2019 Mar. Cancers.11(3).
By:
  • Linder B
  • Weirauch U
  • Ewe A
  • Uhmann A
  • Seifert V
  • Mittelbronn M
  • Harter PN
  • Aigner A
  • Kogel D.

The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma.

  • Luxembourg Center of Neuropathology
March 01, 2019
2019 Mar. Br J Cancer.120(5):481-487. Epub 2019 Feb 12.
By:
  • Foltyn M
  • Luger AL
  • Lorenz NI
  • Sauer B
  • Mittelbronn M
  • Harter PN
  • Steinbach JP
  • Ronellenfitsch MW.

Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma.

  • Luxembourg Center of Neuropathology
February 19, 2019
2019 Feb. Neuro Oncol.21(3):326-336.
By:
  • Eisemann T
  • Costa B
  • Harter PN
  • Wick W
  • Mittelbronn M
  • Angel P
  • Peterziel H.

Pontine tumor in a neonate: case report and analysis of the current literature.

  • Luxembourg Center of Neuropathology
February 15, 2019
2019 Feb. J Neurosurg Pediatr.23(5):606-612. [Epub ahead of print].
By:
  • Buus-Gehrig C
  • Lehrnbecher T
  • Porto L
  • Becker M
  • Freiman T
  • Mittelbronn M
  • Bochennek K.

Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype.

  • Luxembourg Center of Neuropathology
February 14, 2019
2019 Feb. Clin Sarcoma Res.9:2.
By:
  • Koelsche C
  • Stichel D
  • Griewank KG
  • Schrimpf D
  • Reuss DE
  • Bewerunge-Hudler M
  • Vokuhl C
  • Dinjens WNM
  • Petersen I
  • Mittelbronn M
  • Cuevas-Bourdier A
  • Buslei R
  • Pfister SM
  • Flucke U
  • Mechtersheimer G
  • Mentzel T
  • von Deimling A.

Microglia in health and disease: A unique immune cell population. (Book)

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. Michelucci A, Mittelbronn M and Gomez-Nicola D, eds. Lausanne: Frontiers Media, 2018. 106 p. (Frontiers Research topic). ISBN 978-2-88945-601-7.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D
  • et al.

Pre- and early postoperative GFAP serum levels in glioma and brain metastases.

  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. J Neurooncol.139(3):541-546. Epub 2018 May 24.
By:
  • Baumgarten P
  • Quick-Weller J
  • Gessler F
  • Wagner M
  • Tichy J
  • Forster MT
  • Foerch C
  • Seifert V
  • Mittelbronn M
  • Senft C.

EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Luxembourg Center of Neuropathology
September 01, 2018
2018 Sep. EMBO Mol Med.10(9).
By:
  • Dudvarski Stankovic N
  • Bicker F
  • Keller S
  • Jones DT
  • Harter PN
  • Kienzle A
  • Gillmann C
  • Arnold P
  • Golebiewska A
  • Keunen O
  • Giese A
  • von Deimling A
  • Bauerle T
  • Niclou SP
  • Mittelbronn M
  • Ye W
  • Pfister SM
  • Schmidt MHH.

Microglia in health and disease: a unique immune cell population.

  • NORLUX Neuro-Oncology Laboratory
  • Luxembourg Center of Neuropathology
August 15, 2018
2018 Aug. Front Immunol.9:1779.
By:
  • Michelucci A
  • Mittelbronn M
  • Gomez-Nicola D.

Adjuvant therapy using mistletoe containing drugs boosts the T-cell-mediated killing of glioma cells and prolongs the survival of glioma-bearing mice.

  • Luxembourg Center of Neuropathology
July 24, 2018
2018 Jul. Evid Based Complement Alternat Med.2018:3928572.
By:
  • Schotterl S
  • Huber SM
  • Lentzen H
  • Mittelbronn M
  • Naumann U.