Michel Mittelbronn

Latest publications

Application of Raman spectroscopy for detection of histologically distinct areas in Formalin-fixed Paraffin-embedded (FFPE) glioblastoma.

  • Luxembourg Center of Neuropathology
June 18, 2021
2021 Jun. Neurooncol Adv. In press.
By:
  • Klamminger GG
  • Gérardy J-J
  • Jelke F
  • Mirizzi G
  • Slimani R
  • Klein K
  • Husch A
  • Hertel F
  • Mittelbronn M
  • Kleine-Borgmann FB.

FGFR3 overexpression is a useful detection tool for FGFR3 fusions and sequence variations in glioma.

  • Luxembourg Center of Neuropathology
April 01, 2021
2021 Apr. Neurooncol Pract.8(2):209-221.
By:
  • Schittenhelm J
  • Ziegler L
  • Sperveslage J
  • Mittelbronn M
  • Capper D
  • Burghardt I
  • Poso A
  • Biskup S
  • Skardelly M
  • Tabatabai G.

Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma.

  • Luxembourg Center of Neuropathology
April 01, 2021
2021 Apr. Neuropathol Appl Neurobiol.47(3):379-393. Epub 2020 Nov 7.
By:
  • Braun Y
  • Filipski K
  • Bernatz S
  • Baumgarten P
  • Roller B
  • Zinke J
  • Zeiner PS
  • Ilina E
  • Senft C
  • Ronellenfitsch MW
  • Plate KH
  • Bahr O
  • Hattingen E
  • Steinbach JP
  • Mittelbronn M
  • Harter PN.

Microglia in health and disease: The strength to be diverse and reactive.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
March 31, 2021
2021 Mar. Front Cell Neurosci.660523.
By:
  • Uriarte Huarte O
  • Richart L
  • Mittelbronn M
  • Michelucci A.

TGF-beta activates pericytes via induction of the epithelial-to-mesenchymal transition protein SLUG in glioblastoma.

  • Luxembourg Center of Neuropathology
March 29, 2021
2021 Mar. Neuropathol Appl Neurobiol. Online ahead of print.
By:
  • Wirsik NM
  • Ehlers J
  • Mader L
  • Ilina EI
  • Blank AE
  • Grote A
  • Feuerhake F
  • Baumgarten P
  • Devraj K
  • Harter PN
  • Mittelbronn M
  • Naumann U.

Single-cell transcriptomics and in situ morphological analyses reveal microglia heterogeneity across the nigrostriatal pathway.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
March 11, 2021
2021 Mar. Front Immunol.12:639613.
By:
  • Uriarte Huarte O
  • Kyriakis D
  • Heurtaux T
  • Pires-Afonso Y
  • Grzyb K
  • Halder R
  • Buttini M
  • Skupin A
  • Mittelbronn M
  • Michelucci A.

Sarcoma classification by DNA methylation profiling.

  • Luxembourg Center of Neuropathology
January 21, 2021
2021 Jan. Nat Commun.12(1):498.
By:
  • Koelsche C
  • Schrimpf D
  • Stichel D
  • Sill M
  • Sahm F
  • Reuss DE
  • Blattner M
  • Worst B
  • Heilig CE
  • Beck K
  • Horak P
  • Kreutzfeldt S
  • Paff E
  • Stark S
  • Johann P
  • Selt F
  • Ecker J
  • Sturm D
  • Pajtler KW
  • Reinhardt A
  • Wefers AK
  • Sievers P
  • Ebrahimi A
  • Suwala A
  • Fernandez-Klett F
  • Casalini B
  • Korshunov A
  • Hovestadt V
  • Kommoss FKF
  • Kriegsmann M
  • Schick M
  • Bewerunge-Hudler M
  • Milde T
  • Witt O
  • Kulozik AE
  • Kool M
  • Romero-Perez L
  • Grunewald TGP
  • Kirchner T
  • Wick W
  • Platten M
  • Unterberg A
  • Uhl M
  • Abdollahi A
  • Debus J
  • Lehner B
  • Thomas C
  • Hasselblatt M
  • Paulus W
  • Hartmann C
  • Staszewski O
  • Prinz M
  • Hench J
  • Frank S
  • Versleijen-Jonkers YMH
  • Weidema ME
  • Mentzel T
  • Griewank K
  • de Alava E
  • Martin JD
  • Gastearena MAI
  • Chang KT
  • Low SYY
  • Cuevas-Bourdier A
  • Mittelbronn M
  • Mynarek M
  • Rutkowski S
  • Schuller U
  • Mautner VF
  • Schittenhelm J
  • Serrano J
  • Snuderl M
  • Buttner R
  • Klingebiel T
  • Buslei R
  • Gessler M
  • Wesseling P
  • Dinjens WNM
  • Brandner S
  • Jaunmuktane Z
  • Lyskjaer I
  • Schirmacher P
  • Stenzinger A
  • Brors B
  • Glimm H
  • Heining C
  • Tirado OM
  • Sainz-Jaspeado M
  • Mora J
  • Alonso J
  • Del Muro XG
  • Moran S
  • Esteller M
  • Benhamida JK
  • Ladanyi M
  • Wardelmann E
  • Antonescu C
  • Flanagan A
  • Dirksen U
  • Hohenberger P
  • Baumhoer D
  • Hartmann W
  • Vokuhl C
  • Flucke U
  • Petersen I
  • Mechtersheimer G
  • Capper D
  • Jones DTW
  • Frohling S
  • Pfister SM
  • von Deimling A.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

Improved risk stratification in younger IDH wild-type glioblastoma patients by combining a 4-miRNA signature with MGMT promoter methylation status.

  • Luxembourg Center of Neuropathology
December 01, 2020
2020 Dec. Neurooncol Adv.2(1):vdaa137.
By:
  • Unger K
  • Fleischmann DF
  • Ruf V
  • Felsberg J
  • Piehlmaier D
  • Samaga D
  • Hess J
  • Suresh MP
  • Mittelbronn M
  • Lauber K
  • Budach W
  • Sabel M
  • Rodel C
  • Reifenberger G
  • Herms J
  • Tonn JC
  • Zitzelsberger H
  • Belka C
  • Niyazi M.

Cetuximab-mediated protection from hypoxia- induced cell death: implications for therapy sequence in colorectal cancer.

  • Luxembourg Center of Neuropathology
October 20, 2020
2020 Oct. Cancers.12(10).
By:
  • Urban H
  • Maurer GD
  • Luger AL
  • Lorenz NI
  • Sauer B
  • Stroh C
  • Trojan J
  • Mittelbronn M
  • Steinbach JP
  • Harter PN
  • Ronellenfitsch MW.

Blood pressure lowering decreases intracerebral hemorrhage volume and improves behavioral outcomes in experimental animals.

  • Luxembourg Center of Neuropathology
September 29, 2020
2020 Sep. J Stroke.22(3):416-418. Epub 2020 Sep 29.
By:
  • Bohmann FO
  • Seiler A
  • Gelhard S
  • Stolz L
  • Brill B
  • Brunkhorst R
  • Steinmetz H
  • Harter PN
  • Mittelbronn M
  • Foerch C.

Pituitary tumor transforming gene 1 orchestrates gene regulatory variation in mouse ventral midbrain during aging.

  • Neuro-Immunology Group
  • Luxembourg Center of Neuropathology
September 23, 2020
2020 Sep. Front Genet.11(1119).
By:
  • Gui Y
  • Thomas MH
  • Garcia P
  • Karout M
  • Halder R
  • Michelucci A
  • Kollmus H
  • Zhou C
  • Melmed S
  • Schughart K
  • Balling R
  • Mittelbronn M
  • Nadeau JH
  • Williams RW
  • Sauter T
  • Buttini M
  • Sinkkonen L.

Cholinergic innervation and ganglion cell distribution in Hirschsprung's disease.

  • Luxembourg Center of Neuropathology
August 24, 2020
2020 Aug. BMC Pediatr.20(1):399.
By:
  • Braczynski AK
  • Gfroerer S
  • Beschorner R
  • Harter PN
  • Baumgarten P
  • Rolle U
  • Mittelbronn M.

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.

  • Tumor Immunotherapy and Microenvironment
  • Multiomics Data Science
  • Integrated BioBank of Luxembourg
  • Luxembourg Center of Neuropathology
August 01, 2020
2020 Aug. Autophagy.16(8):1436-1452. Epub 2019 Nov 27.
By:
  • Qureshi-Baig K
  • Kuhn D
  • Viry E
  • Pozdeev VI
  • Schmitz M
  • Rodriguez F
  • Ullmann P
  • Koncina E
  • Nurmik M
  • Frasquilho S
  • Nazarov PV
  • Zuegel N
  • Boulmont M
  • Karapetyan Y
  • Antunes L
  • Val D
  • Mittelbronn M
  • Janji B
  • Haan S
  • Letellier E.

HIF-1alpha is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.

  • Luxembourg Center of Neuropathology
August 01, 2020
2020 Aug. Acta Neuropathol.140(2):183-208. Epub 2020 Jun 11.
By:
  • Devraj G
  • Guerit S
  • Seele J
  • Spitzer D
  • Macas J
  • Khel MI
  • Heidemann R
  • Braczynski AK
  • Ballhorn W
  • Gunther S
  • Ogunshola OO
  • Mittelbronn M
  • Kodel U
  • Monoranu CM
  • Plate KH
  • Hammerschmidt S
  • Nau R
  • Devraj K
  • Kempf VAJ.

Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.

  • Integrated BioBank of Luxembourg
  • Transversal Translational Medicine
  • Deep Digital Phenotyping Research Unit
  • PHR Custom Group 2
  • Clinical and Epidemiological Investigation Center
  • Competence Center for Methodology and Statistics
  • Luxembourg Center of Neuropathology
June 09, 2020
2020 Jun. BMC Biol.18(1):62.
By:
  • Baldini F
  • Hertel J
  • Sandt E
  • Thinnes CC
  • Neuberger-Castillo L
  • Pavelka L
  • Betsou F
  • Krüger R
  • Thiele I
  • NCER-PD Consortium (23 collaborators from LIH)
  • Aguayo G
  • Ammerlann W
  • Beaumont K
  • Esteves D
  • Ferrand JY
  • Gantenbein M
  • Geffers L
  • Graas J
  • Hanff AM
  • Hansen M
  • Huiart L
  • Larue C
  • Marques G
  • Menster M
  • Minelli M
  • Mittelbronn M
  • Mommaerts K
  • Nehrbass U
  • Perquin M
  • Schmitz S
  • Trezzi J
  • Vaillant M.

Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors.

  • Luxembourg Center of Neuropathology
May 01, 2020
2020 May. J Clin Invest.130(5):2488-2495.
By:
  • Ronellenfitsch MW
  • Harter PN
  • Kirchner M
  • Heining C
  • Hutter B
  • Gieldon L
  • Schittenhelm J
  • Schuhmann MU
  • Tatagiba M
  • Marquardt G
  • Wagner M
  • Endris V
  • Brandts CH
  • Mautner VF
  • Schrock E
  • Weichert W
  • Brors B
  • von Deimling A
  • Mittelbronn M
  • Steinbach JP
  • Reuss DE
  • Glimm H
  • Stenzinger A
  • Frohling S.

High density DNA methylation array is a reliable alternative for PCR-based analysis of the MGMT promoter methylation status in glioblastoma.

  • Luxembourg Center of Neuropathology
January 01, 2020
2020 Jan. Pathol Res Pract.216(1):152728. Epub 2019 Nov 11.
By:
  • Braczynski AK
  • Capper D
  • Jones DTW
  • Schittenhelm J
  • Stichel D
  • von Deimling A
  • Harter PN
  • Mittelbronn M.

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

  • Luxembourg Center of Neuropathology
January 01, 2020
2020 Jan. Acta Neuropathol.139(1):193-209. Epub 2019 Sep 28.
By:
  • Wefers AK
  • Stichel D
  • Schrimpf D
  • Coras R
  • Pages M
  • Tauziede-Espariat A
  • Varlet P
  • Schwarz D
  • Soylemezoglu F
  • Pohl U
  • Pimentel J
  • Meyer J
  • Hewer E
  • Japp A
  • Joshi A
  • Reuss DE
  • Reinhardt A
  • Sievers P
  • Casalini MB
  • Ebrahimi A
  • Huang K
  • Koelsche C
  • Low HL
  • Rebelo O
  • Marnoto D
  • Becker AJ
  • Staszewski O
  • Mittelbronn M
  • Hasselblatt M
  • Schittenhelm J
  • Cheesman E
  • de Oliveira RS
  • Queiroz RGP
  • Valera ET
  • Hans VH
  • Korshunov A
  • Olar A
  • Ligon KL
  • Pfister SM
  • Jaunmuktane Z
  • Brandner S
  • Tatevossian RG
  • Ellison DW
  • Jacques TS
  • Honavar M
  • Aronica E
  • Thom M
  • Sahm F
  • von Deimling A
  • Jones DTW
  • Blumcke I
  • Capper D.

Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation.

  • Luxembourg Center of Neuropathology
January 01, 2020
2020 Jan. J Neurooncol.146(1):63-69. Epub 2019 Nov 11.
By:
  • Baumann C
  • Tichy J
  • Schaefer JH
  • Steinbach JP
  • Mittelbronn M
  • Wagner M
  • Foerch C.