Guy Berchem

Latest publications

Autophagic degradation of GZMB/granzyme B: a new mechanism of hypoxic tumor cell escape from natural killer cell-mediated lysis.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
January 01, 2014
2014 Jan. Autophagy.10(1):173-5. Epub 2013 Nov 15.
By:
  • Viry E
  • Baginska J
  • Berchem G
  • Noman MZ
  • Medves S
  • Chouaib S
  • Janji B.

The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
December 01, 2013
2013 Dec. Front Immunol.4:490.
By:
  • Baginska J
  • Viry E
  • Paggetti J
  • Medves S
  • Berchem G
  • Moussay E
  • Janji B.

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.

  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
October 22, 2013
2013 Oct. Proc Natl Acad Sci U S A.110(43):17450-5. Epub 2013 Oct 7.
By:
  • Baginska J
  • Viry E
  • Berchem G
  • Poli A
  • Noman MZ
  • van Moer K
  • Medves S
  • Zimmer J
  • Oudin A
  • Niclou SP
  • Bleackley RC
  • Goping IS
  • Chouaib S
  • Janji B.

Stromal cell-induced miRNA alteration in chronic lymphocytic leukemia: how a minute and unavoidable cell contamination impairs miRNA profiling.

  • Tumor Stroma Interactions
August 01, 2013
2013 Aug. Leukemia.27(8):1773-6. Epub 2013 Feb 14.
By:
  • Paggetti J
  • Berchem G
  • Moussay E.

Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F.

  • Tumor Immunotherapy and Microenvironment
February 01, 2013
2013 Feb. J Cell Mol Med.17(2):265-76. Epub 2013 Jan 10.
By:
  • Gabler K
  • Rolvering C
  • Kaczor J
  • Eulenfeld R
  • Mendez SA
  • Berchem G
  • Palissot V
  • Behrmann I
  • Haan C.

Hypoxia-induced autophagy: a new player in cancer immunotherapy?

  • Tumor Immunotherapy and Microenvironment
April 01, 2012
2012 Apr. Autophagy.8(4):704-6. Epub 2012 Apr 1.
By:
  • Noman MZ
  • Janji B
  • Berchem G
  • Mami-Chouaib F
  • Chouaib S.

Lung cancer statistics in Luxembourg from 1981 to 2008.

  • Tumor Immunotherapy and Microenvironment
  • Proteomics of Cellular Signaling
December 01, 2011
2011 Dec. Bull Soc Sci Med Grand Duche Luxemb.(2):43-55.
By:
  • Thill PG
  • Goswami P
  • Berchem G
  • Domon B.

The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain.

  • Tumor Immunotherapy and Microenvironment
October 25, 2011
2011 Oct. BMC Med Genet.12:144.
By:
  • Metzger B
  • Chambeau L
  • Begon DY
  • Faber C
  • Kayser J
  • Berchem G
  • Pauly M
  • Boniver J
  • Delvenne P
  • Dicato M
  • Wenner T.

Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
September 15, 2011
2011 Sep. Cancer Res.71(18):5976-86. Epub 2011 Aug 2.
By:
  • Noman MZ
  • Janji B
  • Kaminska B
  • Van Moer K
  • Pierson S
  • Przanowski P
  • Buart S
  • Berchem G
  • Romero P
  • Mami-Chouaib F
  • Chouaib S.

The acquisition of resistance to TNFalpha in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Platform LUXGEN - Micro-Array
July 01, 2011
2011 Jul. Autophagy.7(7):760-70. Epub 2011 Jul 1.
By:
  • Moussay E
  • Kaoma T
  • Baginska J
  • Muller A
  • Van Moer K
  • Nicot N
  • Nazarov PV
  • Vallar L
  • Chouaib S
  • Berchem G
  • Janji B.

MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Platform LUXGEN - Micro-Array
April 19, 2011
2011 Apr. Proc Natl Acad Sci U S A.108(16):6573-8. Epub 2011 Apr 1.
By:
  • Moussay E
  • Wang K
  • Cho JH
  • van Moer K
  • Pierson S
  • Paggetti J
  • Nazarov PV
  • Palissot V
  • Hood LE
  • Berchem G
  • Galas DJ.

A population based economic analysis of cross-border payments for fertility services in Luxembourg.

  • Public Health Research
October 04, 2010
2010 Oct. J Exp Clin Assist Reprod.7:pii: 3.
By:
  • Jones CA
  • Keith LG
  • Bocquet V
  • Arendt J
  • Smit J
  • Berchem G
  • Lair ML.

The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.

  • Tumor Immunotherapy and Microenvironment
  • Platform LUXGEN - Micro-Array
June 01, 2010
2010 Jun. J Cell Mol Med.14(6A):1264-75. Epub 2009 Oct 3.
By:
  • Janji B
  • Vallar L
  • Al Tanoury Z
  • Bernardin F
  • Vetter G
  • Schaffner-Reckinger E
  • Berchem G
  • Friederich E
  • Chouaib S.

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Platform LUXGEN - Micro-Array
May 01, 2010
2010 May. Mol Cancer.9(1):115. emoussay, vpalissot, lvallar, $, $, velkhoury, naouali, kvanmoer, bleners, fbernardin, .amuller, $, $, $, $, evandyck, gberchem.
By:
  • Moussay E
  • Palissot V
  • Vallar L
  • Poirel HA
  • Wenner T
  • El-Khoury V
  • Aouali N
  • van Moer K
  • Leners B
  • Bernardin F
  • Muller A
  • Cornillet-Lefebvre P
  • Delmer A
  • Duhem C
  • Ries F
  • van Dyck E
  • Berchem G.

The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
  • Platform National Cytometry
April 20, 2010
2010 Apr. Mol Cancer Ther.9(5):1349-60. Epub 2010 Apr 20.
By:
  • El-Khoury V
  • Moussay E
  • Janji B
  • Palissot V
  • Aouali N
  • Brons NH
  • Van Moer K
  • Pierson S
  • Van Dyck E
  • Berchem G.

Challenges with advanced therapy medicinal products and how to meet them.

  • Tumor Immunotherapy and Microenvironment
March 01, 2010
2010 Mar. Nat Rev Drug Discov.9(3):195-201.
By:
  • Committee for Advanced Therapies (CAT) Scientific Secretariat
  • Schneider CK
  • Salmikangas P
  • Jilma B
  • Flamion B
  • Todorova LR
  • Paphitou A
  • Haunerova I
  • Maimets T
  • Trouvin JH
  • Flory E
  • Tsiftsoglou A
  • Sarkadi B
  • Gudmundsson K
  • O'Donovan M
  • Migliaccio G
  • Ancans J
  • Maciulaitis R
  • Robert JL
  • Samuel A
  • Ovelgonne JH
  • Hystad M
  • Fal AM
  • Lima BS
  • Moraru AS
  • Turcani P
  • Zorec R
  • Ruiz S
  • Akerblom L
  • Narayanan G
  • Kent A
  • Bignami F
  • Dickson JG
  • Niederwieser D
  • Figuerola-Santos MA
  • Reischl IG
  • Beuneu C
  • Georgiev R
  • Vassiliou M
  • Pychova A
  • Clausen M
  • Methuen T
  • Lucas S
  • Schussler-Lenz M
  • Kokkas V
  • Buzas Z
  • MacAleenan N
  • Galli MC
  • Line A
  • Gulbinovic J
  • Berchem G
  • Fraczek M
  • Menezes-Ferreira M
  • Vilceanu N
  • Hrubisko M
  • Marinko P
  • Timon M
  • Cheng W
  • Crosbie GA
  • Meade N
  • di Paola ML
  • VandenDriessche T
  • Ljungman P
  • D'Apote L
  • Oliver-Diaz O
  • Buttel I
  • Celis P.

Immune surveillance of human cancer: if the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune?

  • Tumor Immunotherapy and Microenvironment
January 01, 2010
2010 Jan. Tissue Antigens.75(1):1-8.
By:
  • Hamai A
  • Benlalam H
  • Meslin F
  • Hasmim M
  • Carre T
  • Akalay I
  • Janji B
  • Berchem G
  • Noman MZ
  • Chouaib S.