Guy Berchem

Latest publications

High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Tumor Immunotherapy and Microenvironment
May 24, 2018
2018 May. OncoImmunology.7(8):e1465167.
By:
  • Wierz M
  • Janji B
  • Berchem G
  • Moussay E
  • Paggetti J.

Inhibition of HIF1alpha-dependent upregulation of Phospho-l-Plastin resensitizes multiple myeloma cells to frontline therapy.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
May 23, 2018
2018 May. Int J Mol Sci.19(6):1551.
By:
  • Bosseler M
  • Marani V
  • Broukou A
  • Lequeux A
  • Kaoma T
  • Schlesser V
  • Francois JH
  • Palissot V
  • Berchem GJ
  • Aouali N
  • Janji B.

Targeting autophagy in the tumor microenvironment: New challenges and opportunities for regulating tumor immunity.

  • Tumor Immunotherapy and Microenvironment
April 25, 2018
2018 Apr. Front Immunol.9:887.
By:
  • Janji B
  • Berchem G
  • Chouaib S.

Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 25, 2018
2018 Apr. OncoImmunology.7(8):e1452583.
By:
  • Noman MZ
  • Paggetti J
  • Moussay E
  • Berchem G
  • Janji B.

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • Platform National Cytometry
  • Tumor Immunotherapy and Microenvironment
  • NORLUX Neuro-Oncology Laboratory
  • Allergy and Clinical Immunology
April 05, 2018
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
By:
  • Wierz M
  • Pierson S
  • Guyonnet L
  • Viry E
  • Lequeux A
  • Oudin A
  • Niclou SP
  • Ollert M
  • Berchem G
  • Janji B
  • Guerin C
  • Paggetti J
  • Moussay E.

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model.

  • Tumor Stroma Interactions
April 01, 2018
2018 Apr. Haematologica.103(4):e154-e157. Epub 2018 Jan 5.
By:
  • Wierz M
  • Pierson S
  • Chouha N
  • Desaubry L
  • Francois JH
  • Berchem G
  • Paggetti J
  • Moussay E.

Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield.

  • Tumor Immunotherapy and Microenvironment
March 11, 2018
2018 Mar. Autophagy.14(4):730-732. Epub 2018 Mar 11.
By:
  • Noman MZ
  • Berchem G
  • Janji B.

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.

  • Tumor Immunotherapy and Microenvironment
  • Computational Biomedicine
February 15, 2018
2018 Feb. OncoImmunology.7(4):e1345415.
By:
  • Noman MZ
  • Van Moer K
  • Marani V
  • Gemmill RM
  • Tranchevent LC
  • Azuaje F
  • Muller A
  • Chouaib S
  • Thiery JP
  • Berchem G
  • Janji B.

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
  • Platform National Cytometry
October 31, 2017
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
By:
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Noman MZ
  • Viry E
  • Moussay E
  • Van Moer K
  • Kreis S
  • Guerin C
  • Buart S
  • Robert C
  • Borg C
  • Vielh P
  • Chouaib S
  • Berchem G
  • Janji B.

Activation of NK cells and disruption of PD-L1/PD-1 axis: two different ways for lenalidomide to block myeloma progression.

  • Tumor Immunotherapy and Microenvironment
April 04, 2017
2017 Apr. Oncotarget.8(14):24031-24044.
By:
  • Giuliani M
  • Janji B
  • Berchem G.

The critical role of hypoxia in tumor-mediated immunosuppression. In Hypoxia and Human Diseases. (Book Chapter)

  • Tumor Immunotherapy and Microenvironment
February 01, 2017
2017 Feb. Zheng J, ed. Intech, 2017. p.349-364. ISBN 978-953-51-2895-3.
By:
  • Aouali N
  • Bosseler M
  • Sauvage D
  • Van Moer K
  • Berchem G
  • Janji B.

Randomized phase II study of cabazitaxel versus methotrexate in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck previously treated with platinum-based therapy.

  • Tumor Immunotherapy and Microenvironment
December 01, 2016
2016 Dec. Oncologist.21(12):1416-e17. Epub 2016 Nov 30.
By:
  • Machiels JP
  • Van Maanen A
  • Vandenbulcke JM
  • Filleul B
  • Seront E
  • Henry S
  • D'Hondt L
  • Lonchay C
  • Holbrechts S
  • Boegner P
  • Brohee D
  • Dequanter D
  • Louviaux I
  • Sautois B
  • Whenham N
  • Berchem G
  • Vanderschueren B
  • Fontaine C
  • Schmitz S
  • Gillain A
  • Schoonjans J
  • Rottey S.

Hijacker of the antitumor immune response: autophagy is showing its worst facet.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
November 18, 2016
2016 Nov. Front Oncol.6(246):246.
By:
  • Viry E
  • Noman MZ
  • Arakelian T
  • Lequeux A
  • Chouaib S
  • Berchem G
  • Moussay E
  • Paggetti J
  • Janji B.

Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer.

  • Proteomics of Cellular Signaling
October 25, 2016
2016 Oct. Oncotarget.7(43):71013-71035.
By:
  • Bennett CW
  • Berchem G
  • Kim YJ
  • El-Khoury V.

miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.

  • Tumor Immunotherapy and Microenvironment
September 28, 2016
2016 Sep. Cancer Lett.380(1):257-62. Epub 2015 Oct 30.
By:
  • Noman MZ
  • Janji B
  • Berchem G
  • Chouaib S.

A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells.

  • Tumor Stroma Interactions
  • Integrated BioBank of Luxembourg
  • Laboratory of Oncolytic-Virus-Immuno-Therapeutics
July 01, 2016
2016 Jul. Br J Haematol.174(1):57-70. Epub 2016 Mar 11.
By:
  • Medves S
  • Auchter M
  • Chambeau L
  • Gazzo S
  • Poncet D
  • Grangier B
  • Verney A
  • Moussay E
  • Ammerlaan W
  • Brisou G
  • Morjani H
  • Geli V
  • Palissot V
  • Berchem G
  • Salles G
  • Wenner T.

Chapter 12 - Regulation of autophagy in chronic lymphocytic leukemia: The role of Histone Deacetylase Inhibitors. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. (Book Chapter)

  • Proteomics of Cellular Signaling
April 08, 2016
2016 Apr. Academic Press, 2016. p.221–240. (Vol. 9). ISBN 978-0-12-802936-7.
By:
  • El-Khoury V
  • Berchem G.

The multifaceted role of autophagy in tumor evasion from immune surveillance.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 05, 2016
2016 Apr. Oncotarget.7(14):17591-607.
By:
  • Janji B
  • Viry E
  • Moussay E
  • Paggetti J
  • Arakelian T
  • Mgrditchian T
  • Messai Y
  • Noman MZ
  • Van Moer K
  • Hasmim M
  • Mami-Chouaib F
  • Berchem G
  • Chouaib S.

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer.

  • Tumor Immunotherapy and Microenvironment
  • Tumor Stroma Interactions
April 01, 2016
2016 Apr. OncoImmunology.5(4):e1062968. Epub 2015 Jun 24.
By:
  • Berchem G
  • Noman MZ
  • Bosseler M
  • Paggetti J
  • Baconnais S
  • Le Cam E
  • Nanbakhsh A
  • Moussay E
  • Mami-Chouaib F
  • Janji B
  • Chouaib S.

Prospective evaluation of first-Line erlotinib in advanced Non-Small Cell Lung Cancer (NSCLC) carrying an activating EGFR mutation: A multicenter academic phase II study in Caucasian patients (FIELT).

  • Tumor Immunotherapy and Microenvironment
March 31, 2016
2016 Mar. PLoS One.11(3):e0147599.
By:
  • De Greve J
  • Van Meerbeeck J
  • Vansteenkiste JF
  • Decoster L
  • Meert AP
  • Vuylsteke P
  • Focan C
  • Canon JL
  • Humblet Y
  • Berchem G
  • Colinet B
  • Galdermans D
  • Bosquee L
  • Vermeij J
  • Dewaele A
  • Geers C
  • Schallier D
  • Teugels E.