Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid.

  • Personalized Therapy Discovery
  • Disease Modeling & Screening Platform
  • Luxembourg Center of Neuropathology
December 06, 2021 By:
  • Kim H
  • El-Khoury V
  • Schulted N
  • Zhand T
  • Betged J
  • Cousina L
  • Fellif E
  • Pessauxf P
  • Ogiera A
  • Opitzi O
  • Kuj B
  • Ebertd MP
  • Kwon Y-J.

Lung carcinoids are neuroendocrine tumors representing 1 to 2% of lung cancers. This study outlines the case of a patient with a metastatic lung atypical carcinoid who presented with a pleural effusion and progression of liver metastases after developing resistance to conventional treatments. Personalized functional profiling (PFP), i.e. drug screening, was performed in ex-vivo spheroids obtained from the patient’s liver metastasis to identify potential therapeutic options. The drug screening results revealed cediranib, an antiangiogenic drug, as a hit drug for this patient, from a library of 66 Food and Drug Administration (FDA)-approved and investigational drugs. Based on the PFP results and the reported evidence of clinical efficacy of bevacizumab and capecitabine combination in gastro-intestinal neuroendocrine tumors, this combination was given to the patient. Four months later, the pleural effusion and pleura carcinosis regressed and the liver metastasis did not progress. The patient experienced 2 years of a stable disease under the PFP-guided personalized treatment

2021 Dec. Cancer Biol Ther. accepted.
Other information